UTMB
Drs. Niesel and Herzog Medical Discovery News - bridging the world of medical discovery and you...
HomeAbout UsRadio ShowsPodcastListener QuestionsRadio StationsContactsReliable LinksStudents
 

Radio Shows | Mutations and Cancer | mp3wmawav

Mutations and CancerLet’s say you used to smoke like a chimney and bake in the sun. Fast forward twenty years and now you regret the damage you did. Should you worry? Pretty soon your doctor may be able to tell you.

We’re talking about the potential of a simple blood test to reveal if and what mutations have occurred in your cells and whether you face a risk for cancer. If you do, you could then undergo regular testing to catch the disease early on.

The study behind this approach started by sequencing the genome of tumor and healthy tissue in two people. One was a 55 year old who smoked and now has lung cancer.

The other was a 43 year old with melanoma – a deadly skin cancer.

This comparison of the complete DNA sequence of normal and cancerous tissue shows exactly what mutations have occurred. DNA in the lung tumor had an astonishing 33-thousand mutations while the melanoma tissue had over 23-thousand mutations.

And here’s the wake up call: They were able to estimate that smokers accrue about 1 mutation for every pack of cigarettes they smoked.

As for melanoma, most of the mutations were from UV exposure. Talk about a cause and effect!

The data also allowed researchers to distinguish between initial mutations and the cancerous state associated with metastasis and spread to deeper tissues. This way, scientists can identify key mutations and develop drugs to stem their growth.

Now the same work is starting on far more common cancers, such as breast, liver, brain and ovarian cancers.

Scientists hope to be able to identify key mutations of genes in each cancer type. This way a simple blood test can screen for mutations in those genes.

 

Click here to email this page to a friend.


For more information…

A small-cell lung cancer genome with complex signatures of tobacco exposure
Original journal article documenting the mutations that were found in cancer cell genomes associated with smoking exposure.
For more information…

A comprehensive catalogue of somatic mutations from a human cancer genome
This report describes somatic mutations in the genomes of melanoma cancer cells compared to the normal cell genome from the same person. The results describe an accounting of the mutations present in an individual cancer.
For more information…

First cancer genome sequences reveal how mutations lead to disease
Article from Ian Sample of the Guardian News describing these studies.
For more information…

The Role of Mutation in Cancer
Emory university website that provides an overview of the link between cancer and mutations.
For more information…

 
 

home | about us | radio shows | podcast | listener questions | radio stations | contact us | links | students | disclaimer

©2006-2007 Drs. David Niesel and Norbert Herzog. All Rights Reserved.
The University of Texas Medical Branch. Please review our site policies.
Send mail to J. Junemann with questions or comments about this web site.